Aubade Blend Personality
The fragrance of a bouquet of flowers. Medium roast coffee. Delicate taste and equally delicate body. A hint of smoke that ends in a clean finish
A Touch of Sweetness
A coffee easily enhanced with any sweetener. Add in sugar to bring out the crisp taste. Savor a velvety caffé latte with a little sugar and generous amount of milk
Functional herb extracts
Echinacea purpurea (Eastern purple coneflower)
Benefits of functional herb
Eastern purple coneflower is a traditional tonic for respiratory health
The extraordinary JoyAmaze™ Herbal Coffee series
- Revive your mind and body with the anytime coffee, the Vivo Blend
- Relax and unwind with the smooth and easy Calmando blend
- Start each new day with fresh, invigorating and engaging Aubade Blend
- Health Note
All information in these sections have not been evaluated by the FDA. They are only to provide general information to user. They are not intended to diagnose, treat, cure, or prevent any disease. Read More
I accept all of the above terms by clicking here or by any further use of this service.
I do not accept any or all of the above terms.
Scientific Information (Did You Know?)
A. Clinical Studies of EchinaceaFunction 1: Immune function
The orogastric administration studies with three different Echinacea species have proven them to be the effective immunomodulators. It was found that the three different species of Echinacea (Echinacea angustifolia, Echinacea pallida and Echinacea purpurea) exhibit multiple modulating effects on immune function. Besides stimulating nonspecific, innate immune response, they also support specific, adaptive immune function. This suggests that Echinacea possesses an immunomodulating potential for the overall immune system1.
Echinacea preparations are commonly used as nonspecific immunomodulatory agents. Alcohol extracts from three species of Echinacea were investigated on mice for immunomodulating properties. The mice were forced-fed or gavaged once a day (for 7 days) with one of the Echinacea extracts (130mg/kg) or vehicle and immunized with sheep red blood cells (sRBC) 4 days prior to collection of immune cells for multiple immunological assays. The three herb extracts induced similar but differential, changes in the percentage of immune cell populations and their biological functions; increased percentages of CD49+ and CD19+ lymphocytes in spleen and natural killer cell cytotoxicity. Antibody response to sRBC was significantly increased equally by extracts of all three Echinacea species. The Echinacea treatment significantly altered the cytokine production by mitogen stimulated splenic cells. The three herbal extracts significantly increased interferon-γ production, but inhibited the release of tumor necrosis factor-α and interleukin (IL)-1β. E. angustifolia- and E. pallida-treated mice demonstrated significantly higher production of IL-4 and increased IL-10 production. These findings demonstrated that Echinacea is a wide-spectrum immunomodulator that modulates both innate and adaptive immune responses. In particular, E. angustifolia or E. pallida may have more anti-inflammatory potential1.Function 2: Common cold
A human study was conducted to investigate the safety (risk) and the efficacy (benefit) of Echinacea purpurea extract in the prevention of common cold episodes in a large population over a 4-month period. The result showed that it has provided a positive risk to benefit ratio2.
755 healthy subjects were allocated to receive either an alcohol extract from freshly harvested E. purpurea (95% herba and 5% root) or placebo. The participants were asked to record the adverse events and to rate cold related issues throughout the investigation period. There was a total of 293 adverse events occurred with Echinacea and 306 with placebo treatment (9% and 10% of the participants respectively). This is possibly related to the study drug (adverse drug reactions), thus the safety of Echinacea was non-inferior to placebo. Echinacea has reduced the total number of cold episodes, cumulated episode days within the group and pain-killer medicated episodes. It has also inhibited virally confirmed colds and particularly prevented enveloped virus infections. Hence, it is concluded that compliant prophylactic intake of E. purpurea over a 4-month period appeared to provide a positive risk to benefit ratio2.Function 3: Wound healing
The open skin wound healing begins with an inflammatory response. The effect of Echinacea as an agent for anti-inflammation has been investigated by an animal study with mice. The positive outcome of the study has suggested that oral administration of Echinacea may be attributable to its readily bioavailable alkamides or ketones (corticosterone)3.
It has been well documented that restraint stress tends to delay wound closure, partially via glucocorticoid (GC)- mediated immunosuppression of inflammation. Thus, an alcohol extract of Echinacea pallida was orally administrated for mice for 3 days prior to and 4 days post wounding with a dermal biopsy on the dorsum. Concurrently, mice were exposed to 3 cycles of daily restraint stress prior to and 4 cycles post wounding. The result analysis has proven that Echinacea accelerated wound closure in the stressed mice, however had no apparent wound healing effect for the non-stressed mice. In order to test the possibility of GC release modulation in positive healing effect, the plasma corticosterone concentrations were measured in unwound mice treated with restraint stress and the herbal extract for 4 days. Plasma GC in restraint stressed mice gavaged with Echinacea was not different from mice treated with restraint only, but was increased compared to the vehicle control. The data showed, improved wound healing effect of Echinacea in stressed mice is not mediated through modulation of GC signaling but Echinacea itself possess a high level of corticosterone which helps in wound healing3.
Another animal study was conducted to evaluate the healing effect of Echinacea extract in Arsenic induced dermal necrosis in rat. The research findings reported that Echinacea has healing effects and can protect and limit the Arsenic effects4.
The experimental study was conducted with 20 male Wistar rats. They were divided into two groups. Dermal necrosis was induced by subcutaneous arsenic injection (4mg/kg) for 10 days. The group 2 rats were injected intraperitoneally with Echinacea (400mg/kg) after receiving arsenic. After the last day of injection, rats were euthanizes and pathologic samples were collected from dermal ulcers. The histopathologic results revealed necrosis of different dermal layers in arsenic group. There were inflammatory exudates instead of impaired structures. In Echinacea receiving group, exudate and flocculation on the wound was much lower than the control group. In contrast, there were granulation tissue with high cellularity and new vessels in the wound site. Hence, the study has revealed that Echinacea purpurea hydroalcoholic extract had anti-inflammatory, anti-oxidative, anti-bacterial, a high healing potential and had significantly limited the arsenic impacts4.Function 4: Reduce infections
It was evidenced by human study that certain phytochemicals have the capacity to ameliorate tumors and reduce infections, especially those mediated by virus, in vivo. Thus, an attempt was made to investigate the potentially immuno-stimulating effect of one such phytocompound, Echinacea purpurea, on natural killer (NK) cells since these cells are active in spontaneous, non-specific immunity against neoplasms and virus-mediated infections. The study with mice has proved that Echinacea had the capacity to increase NK cell numbers5.
It was previously found in another study that, neither the cytokine, interleukin-2, nor the pharmacological agent, indomethacin, both potent stimulators of NK cell numbers or function in younger adult mice. However, it was effective in stimulating NK cells in elderly mice. Hence, the study was designed to assess the numbers or production of NK cells in the spleen and bone marrow of aging, normal mice, after in vivo dietary administration of E. purpurea (14 days), or, after injection of thyroxin, a stimulant of NK cell function (10 days). The results revealed that E. purpurea, but not thyroxin had the capability to increase NK cell numbers in aging mice. This reflects increased new NK cell production in their bone marrow generation site, leading to an increase in the absolute numbers of NK cells in the spleen which is their primary destiny5. The E. purpurea-mediated increase in NK cell numbers was indeed paralleled by an increase in their anti-tumor, lytic functional capacity. Collectively, the data indicate that E. purpurea, at least, and possibly other plant compounds, appear to contain phytochemicals capable of stimulating de novo production of NK cells, as well as augmenting their cytolytic function, in animals of advanced age5.Function 5: Gingivitis
An herbal mouth rinse (HM-302, Izun Pharmaceuticals Corp., www.izunpharma.com) containing the herbs Centella asiatica, Echinacea purpurea, and Sambucus nigra was developed for the purpose of treating gingivitis. Clinical experience of the authors has shown this rinse to be effective in reducing gingival inflammation6.
This study was designed as a prospective, interventional, double-blinded, randomized, placebo-controlled trial. Severity of gingival inflammation was evaluated using the GI (gingival index) as the primary outcome measure. The PI (plaque index), which is a scoring system that characterizes the extent of dental plaque was also taken in count. The number of bleeding sites per patient was determined by assessment of bleeding-upon-probing (BoP). Following initial evaluation, all subjects underwent a full dental prophylaxis treatment, which included both scaling and tooth polishing. Following initial assessment, all subjects were instructed to abstain from brushing their teeth or using any other oral hygiene technique (flossing, using commercial mouth rinses or breath mints, etc.). The only treatment allowed was washing with 15 mL of one of the study mouth rinse products, which was to be used three times daily for 14 days. On day 14, patients were re-examined, and GI, PI, and BoP were evaluated. Subjects were then given full dental prophylaxis and instructed to return to their original oral hygiene regimen. The HM-302 mouthwash was acceptable to all of the subjects in the treatment group, with no serious adverse effects reported. The most commonly reported effect (by 3 of 15 subjects) was a slight staining of the teeth, which was consistent with all other rinses in the trial. Nevertheless, the findings of this pilot study are significant and suggest that HM-302 has the potential to mitigate the host inflammatory response to plaque and reduce levels of gingival inflammation due to the presence of herbs with reported antibacterial and anti-inflammatory properties6.Function 6: Tumor Amelioration
It was hypothesized that immunization of mice with killed erythroleukemia cells prior to the induction of erythroleukemia via injection of viable tumor cells, plus dietary administration of a known immuno-enhancing phytocompound, Echinacea purpurea, would be more effective than immunization alone7.
A commercially available extract of E.purpurea root was administrated via the chow for periods of 9 days or 3 months after the onset of leukemia to mice which had been injected (immunized) 5 weeks earlier with killed leukemia cells. Immunized mice (given E.purpurea extract) had significantly prolonged life spans versus non-immunized mice. The E.purpurea-fed group even had a high long-term hosts surviving rate. NK cells, the mediators of nonspecific immunity and well-demonstrated mediators of tumor cytolysis, were very significantly elevated in immunized, leukemic mice receiving E.purpurea in their diet compared to those receiving untreated chow. Early in tumor development (9 days), cells mediating specific immunity (T, B lymphocytes) were 10-12 times higher in absolute numbers in the spleens in all immunized, leukemic mice compared to unimmunized, leukemic mice at the same stage of tumor progression. Hence, it was concluded that combination therapy, involving specific tumor cell immunization, followed by daily phytotherapy (dietary E.purpurea), sensitized the immune cells and led to life span prolongation greater than that provided by immunization alone7.References
Zhai, Z., Liu, Y., Wu, L., Senchina, D.S., Wurtele, E.S., Murphy, P.A., Kohut, M.L., Cunnick, J.E. (2007). Enhancement of innate and adaptive immune functions by multiple Echinacea species. Journal of Medicinal Food 10(3): 423-434
Jawad, M., Schoop, R., Suter, A., Klein, P., Eccles, R. (2012). Safety and efficacy profile of Echinacea purpurea to prevent common cold episodes: a randomized, double-blind, placebo-controlled trial. Evidence Based Complementary and Alternative Medicine doi: 10.1155/2012/841315
Zhai, Z., Haney, D.M., Wu, L., Solco, A.K., Murphy, P.A., Wurtele, E.S., Kohut, M.L., Cunnick, J.E. (2009). Alcohol extract of Echinacea pallida reverses stress-delayed wound healing in mice. Phytomedicine 16(6-7): 669-678
Rezaie, A., Najafzadeh, H., Poormahdi, M.B., Mohammadian, B., Heidari, M. (2013). Effect of Echinacea purpurea on wound healing after arsenic induced skin necrosis. Zahedan Journal of Research in Medical Sciences 15(11): 19-23
Currier, N.L. & Miller, S.C. (2000). Natural killer cells from aging mice treated with extracts from Echinacea purpurea are quantitatively and functionally rejuvenated. Experimental Gerontology 35(5): 627-639
Samuels, N., Grbic, J.T., Saffer, A.J., Wexler, I.D., Williams, R.C. (2012). Effect of an herbal mouth rinse in preventing periodontal inflammation in an experimental gingivitis model: a pilot study. Compendium 33(3): 204-2011
Currier, N.L. & Miller, S.C. (2002). The effect of immunization with killed tumor cells, with/without feeding of Echinacea purpurea in an erythroleukemic mouse model. Journal of Alternative Complimentary Medicine 8(1): 49-58